Mr Warmbier’s family announced the news via an emotional statment from Ohio.
Warmbier, who was imprisoned in North Korea for 17 months, was returned home in a coma less than a week ago.
He died in a Cincinnati hospital, his family said in a statement on Monday.
Otto was returned from North Korea in a coma, not able to understand language and had severe brain damage.
Authorities in Kim Jong-Un’s North said he had fallen ill with food poisoning and taken a sleeping tablet – which doctors in the US find no evidence of.
“Unfortunately, the awful torturous mistreatment our son received at the hands of the North Koreans ensured that no other outcome was possible beyond the sad one we experienced today,” the family said in a statement.
Otto Warmbier has died after being detained in North Korea
Otto Warmier broke down as he was jailed in North Korea
The statement said: “It is our sad duty to report that our son, Otto Warmbier, has completed his journey home. Surrounded by his loving family, Otto died today at 2.20pm.
“It would be easy at a moment like this to focus on all that we lost – future time that won’t be spent with a warm, engaging, brilliant young man whose curiosity and enthusiasm for life knew no bounds.
“But we choose to focus on the time we were given with this remarkable person.”
President Donald Trump said Warmer faced tough conditions and that North Korea is a “brutal regime”.